Sculptra vs. Profhilo: Which Injectable Treatment Is Best?

Sculptra vs Profhilo! Two amazing injectable treatments go head to head.

Today, we compare the two and show you the difference between Sculptra and Profhilo.

Let’s compare!

What’s the difference between Sculptra and Profhilo?

These two treatments both aim to improve skin quality and appearance, but they vary significantly in their ingredients and mechanism of action.

Sculptra is made from Poly L lactic acid, while Profhilo is made from hyaluronic acid

Both are considered fantastic treatments and will give great results for most skin concerns, but depending on your skin goal, you might find one more beneficial than the other treatment.

Let’s explain in more detail.

Ingredients of Sculptra and Profhilo

Sculptra Ingredients

Sculptra’s main ingredient is Poly L lactic acid (PLLA) which has the primary purpose of stimulating collagen production and improving skin tone.

The other ingredients include:

  • Carboxymethylcellulose (CMC)
  • Non-pyrogenic mannitol
  • Sterile water

These extra ingredients are mostly stabilisers and carriers for the PLLA to increase shelf life and efficiency.

Profhilo Ingredients

Profhilo consists of a blend of high-molecule-weight hyaluronic acid (HMW-HA) and low-molecule-weight hyaluronic acid (LMW-HA).

The HMW is included for slower absorption which means hydration will be longer lasting throughout the skin tissue.

The LMW is a smaller molecule which means it’s absorbed more easily for instant hydration and the stimulation of collagen and elastin.

The only other ingredient is Phosphate-buffered saline (PBS) which just helps to blend the hyaluronic acid and make it easier for injection.

What makes Profhilo different from traditional derma fillers is it does not contain cross-linking agents, which means the consistency is not a gel, and the risk of allergic reaction is almost non-existent.

The Mechanism of How Sculptra and Profhilo Work

Sculptra Mechanism of Action

Sculptra treatment works as a collagen production mechanism and helps the body produce skin thickness and improve skin texture and overall skin appearance.

Profhilo Mechanism of Action

It works by providing deep hydration and rejuvenation to the skin. As the HA molecules spread throughout the treated area, they improve skin elasticity, firmness, and overall quality.

Profhilo provides hydration via hyaluronic acid, which helps to:

  • Rejuvenate the skin
  • Stimulate collagen production
  • Improve skin laxity
  • Improve skin elasticity
  • Improve skin firmness
  • Improve overall texture and quality

Treatment Areas Profhilo vs Sculptra

Sculptra Treatment Area

Similar to dermal fillers, Sculptra treatments are designed to treat facial volume loss (lost volume), facial contours, and deep lines and wrinkles (or folds, such as nasolabial folds and marionette lines).

Profhilo Treatment Area

It is mainly used for skin rejuvenation and hydration, targeting sagging, tired, or dehydrated skin which will bring about a natural glow and collagen growth (collagen synthesis).

Common treatment areas include:

  • Face (and lower face)
  • Neck
  • Décolletage
  • Hands
  • Knees


Sculptra Results

The results from Sculptra treatment are gradual, and they will be more noticeable as time goes on.

The results can last upwards of 2 years, but this will depend on how many treatments you get and how your body reacts to them.

Most patients are happy with their results after a few months.

Profhilo Results

Profhilo also has a slow burn, but results are usually noticeable a few weeks after the second treatment.

You should expect results to last 6-12 months.

You will need to top up every 6 months to maintain your results with bio-remodelling treatments like Profhilo.

Side Effects

Both of these treatments have similar side effects to any cosmetic injectables.

You may experience some redness, swelling, bruising or needle bumps on the injection sites, but these should go away on their own within a day or two.

Verdict – Which treatment is better, Sculptra or Profhilo?

It Depends! If you’re looking for overall skin health and fantastic skin tone and radiance, then Profhilo is the way to go.

If you need to add some volume to the face, you’re better off with Sculptra treatments.

Either way, we know you’ll love the result, and it’s well worth the money spent.


profhilo vs sculptra - FAQ - Australia
Profhilo vs Sculptra – FAQ – Australia

Is Sculptra better than Profhilo?

Sculptra treatment is not better than Profhilo but is also not worse.

They are two different treatments that have different goals in mind.

If you need volume, go for Sculptra; if you need an overall healthy look, go for Profhilo.

Is there anything better than Sculptra?

Again, this is subjective and related to the patient’s skin goals.

Both Sculptra and Profhilo are at the top when it comes to improving your skin in an advanced clinical setting.

Almost everyone who tries these treatments are happy with the results.

What is better than Profhilo?

To be honest, not much.

We rate Profhilo very highly, and it’s only a matter of time before it’s as popular as things like Botox.

It stimulates collagen synthesis and, over time, will make the skin look better and better.

If you want a treatment that will give you good results but also slow down ageing over the long term, Profhilo is what you need.

What is the downside of Sculptra?

As with any cosmetic injectables, the main downside is the small risks from the injections themselves.

Ensure your doctor explains all the risks to you, including things like redness, tenderness and bruising.

We think the results far outweigh the risks, which is why these are the most popular options for an in-clinic cosmetic procedure.


The human body is amazing!

We’ve advanced so far from your traditional dermal fillers (to add volume).

Through clinical trials and years of experience with all types of anti-wrinkle injections, we’re now in a place where we can get exceptional results with little to no risk.

If you’ve tried other treatments and didn’t achieve optimal results, then we know the gradual results provided by one of these treatments will be a great success for you.

So there you have it! It’s now up to you to decide; Sculptra or Profhilo.

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